Case report: Nicolau síndrome in a pediatric patient

Authors

  • Jorge Alberto Diaz Gonzalez *Médico Residente de Posgrado de Pediatría Universidad Nacional Autónoma de Honduras.
  • José Daniel Almazán Monroy *Médico Residente de Posgrado de Pediatría Universi dad Nacional Autónoma de Honduras. https://orcid.org/0000-0003-3043-0231
  • Marlen Vanessa Orellana *Médico Residente de Posgrado de Pediatría Universi dad Nacional Autónoma de Honduras.

Keywords:

Nicolau syndrome, embolism cutis medicamenta, benzathine penicillin

Abstract

Nicolau syndrome or embolism cutis medicamenta or livedoid dermatitis, is a rare syndrome in pediatrics that presents as a complication of an intramuscular injection with multiple degrees of tissue damage, including skin and deep tissue necrosis. We report the case of a 2-year-old male patient, with no pathological history, who attended the pediatric emergency department of the "Mario Catarino Rivas" Hospital (HMCR) in San Pedro Sula, Cortes, with a history of presenting a necrotic lesion in the lower extremity. and left buttock, painful on palpation, which appeared after the administration of a compound medication intramuscularly. Physical examination revealed an extensive necrotic plaque that was painful on palpation and on movement of the limb, with preserved peripheral pulses and no distal coldness. Through a multidisciplinary approach, surgical cleaning, antibiotic coverage, antithrombotic management, and grafting were provided, with favorable evolution, for which we emphasize that timely multidisciplinary identification and management is essential.

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Author Biographies

Jorge Alberto Diaz Gonzalez , *Médico Residente de Posgrado de Pediatría Universidad Nacional Autónoma de Honduras.

1. Tovar Noroña, C. E., Romero Villegas, C. M., & Jaramillo Gómez, D. X. (2021). Síndrome de Nicolau, una patología infrecuente tras la adminitración de penicilina benzatinica. Mediciencias UTA, 5(1), 31–36.
2. Mojarrad P, Barikbin B, Oghazian MB. Can betamethasone prevent Nicolau syndrome when coad ministered with penicillin? A case report. ClinCase Rep. 2021 Dec 7;9(12):e05187. doi: 10.1002/ ccr3.5187. PMID: 34934500; PMCID: PMC8650753.
3. Goudjo, E. U. E. M., Metchihoungbe, C. S., Mihlue do-Agbolan, A. K., Houegban, A. S. C. R., Miaffo, O. E. D. D., Kante, T. B., Sanni, Y. S., & Gnassingbe, K. (2022). Nicolau syndrome: A series of three cases following drug’s intramuscular injection in children. Journal of Pediatric Surgery Case Reports, 80(102181), 102181.
4. Chae, Dong-Sik. (2015). Nicolau syndrome: A literature review. 10.13140/RG.2.1.2619.0243.
5. Alkadi, R. A., Hudna, A. S., Al-Shehab, M. A., & Alzomor, O. (2022). Nicolau syndrome in a child caused by penicillin injection. Journal of clinical and diagnostic research: JCDR.
6. Álvarez, Alejandra & Muñoz, Mónica. (2020). Síndrome de Nicolau o embolia cutis medicamentosa: a propósito de un caso. Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica. 28. 264-268. 10.29176/2590843X.1536.

José Daniel Almazán Monroy , *Médico Residente de Posgrado de Pediatría Universi dad Nacional Autónoma de Honduras.

1. Tovar Noroña, C. E., Romero Villegas, C. M., & Jaramillo Gómez, D. X. (2021). Síndrome de Nicolau, una patología infrecuente tras la adminitración de penicilina benzatinica. Mediciencias UTA, 5(1), 31–36.
2. Mojarrad P, Barikbin B, Oghazian MB. Can betamethasone prevent Nicolau syndrome when coad ministered with penicillin? A case report. ClinCase Rep. 2021 Dec 7;9(12):e05187. doi: 10.1002/ ccr3.5187. PMID: 34934500; PMCID: PMC8650753.
3. Goudjo, E. U. E. M., Metchihoungbe, C. S., Mihluedo-Agbolan, A. K., Houegban, A. S. C. R., Miaffo, O. E. D. D., Kante, T. B., Sanni, Y. S., & Gnassingbe, K. (2022). Nicolau syndrome: A series of three cases following drug’s intramuscular injection in children. Journal of Pediatric Surgery Case Reports, 80(102181), 102181.
4. Chae, Dong-Sik. (2015). Nicolau syndrome: A literature review. 10.13140/RG.2.1.2619.0243.
5. Alkadi, R. A., Hudna, A. S., Al-Shehab, M. A., & Alzomor, O. (2022). Nicolau syndrome in a child caused by penicillin injection. Journal of clinical and diagnostic research: JCDR.
6. Álvarez, Alejandra & Muñoz, Mónica. (2020). Síndrome de Nicolau o embolia cutis medicamentosa: a propósito de un caso. Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica. 28. 264-268. 10.29176/2590843X.1536.

Marlen Vanessa Orellana, *Médico Residente de Posgrado de Pediatría Universi dad Nacional Autónoma de Honduras.

1. Tovar Noroña, C. E., Romero Villegas, C. M., & Jaramillo Gómez, D. X. (2021). Síndrome de Nicolau, una patología infrecuente tras la adminitración de penicilina benzatinica. Mediciencias UTA, 5(1), 31–36.
2. Mojarrad P, Barikbin B, Oghazian MB. Can betamethasone prevent Nicolau syndrome when coad ministered with penicillin? A case report. ClinCase Rep. 2021 Dec 7;9(12):e05187. doi: 10.1002/ ccr3.5187. PMID: 34934500; PMCID: PMC8650753.
3. Goudjo, E. U. E. M., Metchihoungbe, C. S., Mihluedo-Agbolan, A. K., Houegban, A. S. C. R., Miaffo, O. E. D. D., Kante, T. B., Sanni, Y. S., & Gnassingbe, K. (2022). Nicolau syndrome: A series of three cases following drug’s intramuscular injection in children. Journal of Pediatric Surgery Case Reports, 80(102181), 102181.
4. Chae, Dong-Sik. (2015). Nicolau syndrome: A literature review. 10.13140/RG.2.1.2619.0243.
5. Alkadi, R. A., Hudna, A. S., Al-Shehab, M. A., & Alzomor, O. (2022). Nicolau syndrome in a child caused by penicillin injection. Journal of clinical and diagnostic research: JCDR.
6. Álvarez, Alejandra & Muñoz, Mónica. (2020). Síndrome de Nicolau o embolia cutis medicamentosa: a propósito de un caso. Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica. 28. 264-268. 10.29176/2590843X.1536.

Published

2025-12-10

How to Cite

Diaz Gonzalez , J. A., Almazán Monroy , J. D., & Orellana, M. V. (2025). Case report: Nicolau síndrome in a pediatric patient. Acta Pediátrica Hondureña, 12(2), 1286–1280. Retrieved from https://www.camjol.info/index.php/PEDIATRICA/article/view/21104