Chronic Myeloproliferative Neoplasms: Comparison of Cytological and Histological Findings.

Abstract

Introduction: In the diagnostic approach to Chronic myeloproliferative neoplasms, the study of the bone marrow, which includes biopsy and aspiration, is essential because both diagnostic methods are complementary. The objective of the study was to determine the existing concordance between bone marrow biopsy and cytology in the diagnosis of the different types of chronic myeloproliferative neoplasms. Material and method: This is a descriptive, cross-sectional study carried out at the Dr. Manolo Morales Peralta teaching hospital between January 2016 and December 2018. A sample of 30 biopsies was selected by convenience to define the cytological and morphological findings that favored the diagnosis and their relationship. Results and discussion: Of the 30 diagnosed biopsies, an overall positive concordance of 73.33% was observed. The distribution of each of the characteristics evaluated, such as age groups, clinical features, and laboratory parameters, are consistent with those described for most of these pathological processes. The highest concordance rate during the diagnostic approach was in Chronic myeloid leukemia (CML) at 90%, Polycythemia vera at 75%, and Essential thrombocythemia at 50%. There was no concordance with Myelofibrosis. Conclusion: Good concordance was identified between biopsy and bone marrow aspirate in the diagnosis of chronic myeloproliferative neoplasms.